Senescent fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity
Jin Young Lee, Nabora S. Reyes, Sang‐Ho Woo, Nancy C. Allen, Tsukasa Kadota, Andrew J. Lechner, Ritusree Biswas, Sakshi Goel, Fia Stratton, Chaoyuan Kuang, Tatsuya Tsukui, Vincent C. Auyeung, Aaron Scott Mansfield, Lindsay M. LaFave, Tien Peng
This study identifies senescent fibroblasts in lung cancer stroma that alter tumor metabolism and plasticity, and shows that targeting these cells with XL888 reduces tumor burden.
Cell stem cell · Nov 3, 2025Peer-reviewedCancer Biology