Mark R. Looney

The paper identifies emperipolesis as a process where megakaryocytes transfer proteins to neutrophils, enhancing their immune function and migration.

This study shows that GPCR-Ga13 signaling is essential for intestinal IEL survival by enabling migration to cytokine-rich niches, with loss of G13 leading to impaired function and increased disease severity.

This study shows that the local lung environment, not the peripheral environment, drives phenotypic diversity in monocyte-derived lung cells during Mtb infection.

This study shows that furin inhibition with BOS-318 reduces acute lung injury and improves survival in mouse models of Pseudomonas aeruginosa infection.

This study shows that aged fibroblasts activate NF-kB, leading to immune changes like exhausted T cells, autoimmunity, and cancer, increasing susceptibility to age-related diseases.

This paper develops a technique for intravital imaging of pulmonary lymphatics in mice, revealing ventilation-dependent and -independent lymph flow and leukocyte migration during inflammation and cancer metastasis.

This study shows that loss of neutrophil Shp1 causes severe lung injury and death in mice, and that activating Shp1 can reduce inflammation and lung damage.

This study shows that IgG hexamerization is critical for triggering acute lung injury and suggests therapeutic strategies targeting hexamer formation.