A systematic search for RNA structural switches across the human transcriptome
Matvei Khoroshkin, Daniel E. Asarnow, Shaopu Zhou, Albertas Navickas, Aidan F. Winters, Jackson Goudreau, Simon K. Zhou, Johnny X. Yu, Christina Palka, Lisa Fish, Ashir A. Borah, Kian Yousefi, Christopher F Carpenter, Karl Mark Ansel, Yifan Cheng, , Hani Goodarzi
The paper identifies 245 putative RNA structural switches in the human transcriptome using a computational and experimental approach, validates one with DMS-MaPseq and cryo-EM, and shows its regulation by trans factors and nonsense-mediated decay.
Nature Methods · Jul 16, 2024Peer-reviewedSystems Biology