Karl Mark Ansel

This study identifies allergen-reactive Th2 cells in human airways using high-dimensional profiling and shows their systemic expansion following allergen challenge.

The paper shows that gap junctions between breast cancer cells and adipocytes transfer cAMP, activating lipolysis in the tumor microenvironment to support tumor growth.

PROPEL is a postbaccalaureate program that trains scholars from underrepresented backgrounds in biomedical research, demonstrating its scalability and impact.

The paper identifies 245 putative RNA structural switches in the human transcriptome using a computational and experimental approach, validates one with DMS-MaPseq and cryo-EM, and shows its regulation by trans factors and nonsense-mediated decay.

This study shows that miR-15/16 in Tregs is essential for immune tolerance by restricting proliferation and maintaining suppressive function, preventing inflammation.

The paper develops ImReP, a computational method to profile TCR and BCR repertoires from RNA-seq data, creating a large atlas of immunological sequences across 53 tissues.

The paper develops GCLiPP to map RNA binding protein occupancy and identifies cis-regulatory elements in T cell 3' UTRs, revealing shared regulatory mechanisms across human and mouse.