STING activation reshapes the tumor microenvironment leading to tumor regression in osteosarcoma
Elizabeth P. Young, Christine A. Johnson, Alex Gia Lee, Douglass Morris, Jessica L. Tsui, Marcus R. Breese, Juan A. Cámara, Courtney R. Schott, Clare L. Abram, Stanley G. Leung, Leanne C. Sayles, Aafrin M. Pettiwala, Vanessa S. Gutierrez Vera, Clifford A. Lowell, Alexis J. Combes, , Alejandro Sweet-Cordero
This study shows that activating the STING pathway in osteosarcoma leads to tumor regression and immune memory, suggesting it as a therapeutic target.
bioRxiv · Oct 24, 2025 · PreprintCancer Biology