Author

Leanne C. Sayles

University of California, San FranciscoORCID 0000-0003-3963-6412Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

Alejandro Sweet-CorderoiD· 2 shared Aafrin M. PettiwalaiD· 1 shared Alex Gia LeeiD· 1 shared Alexis J. CombesiD· 1 shared Catherine RheeiD· 1 shared Christine A. Johnson· 1 shared Clare L. AbramiD· 1 shared Clifford A. LowelliD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

Alejandro Sweet-CorderoORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 24, 2025

STING activation reshapes the tumor microenvironment leading to tumor regression in osteosarcoma

Elizabeth P. Young, Christine A. Johnson, Alex Gia Lee…·Alejandro Sweet-Cordero

This study shows that activating the STING pathway in osteosarcoma leads to tumor regression and immune memory, suggesting it as a therapeutic target.

2 citations

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintApr 25, 2025

Interrupting ELMSAN1 repression of nuclear Acetyl-CoA production therapeutically reprograms cancer cells

Ting Zhao, Lingli He, Lai Ping Wong…·David T. Scadden

The paper identifies ELMSAN1 as a repressor of nuclear acetyl-CoA production and shows that inhibiting this interaction reprograms cancer cells to a postmitotic state, improving survival in multiple cancer models.

DOI 10.1101/2025.04.25.650293

humanproteomics

𝕏 PostBluesky