Author

Christopher F. Thomas

Boston University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:machine learning (classical)· 1 Research Focus:perturbation response prediction· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Cynthia A. BradhamiD· 3 shared Dakota Y. Hawkins· 2 shared Daniel T. ZuchiD· 2 shared Viktoriya Skidanova· 2 shared Abigail E. DescoteauxiD· 1 shared Abigail Glick· 1 shared Alexandra T. LioniD· 1 shared Daphne Schatzberg· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersDevelopmental Biology

Cynthia A. BradhamORCID

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Author profile →

3 papers

Recent·Most cited

Voltage-gated sodium channel activity mediates sea urchin larval skeletal patterning through spatial regulation of Wnt5 expression

Christopher F. Thomas, Dakota Y. Hawkins, Viktoriya Skidanova, Simone R Marrujo, Janay Gibson, Ziqing Ye, Cynthia A. Bradham

The paper shows that voltage-gated sodium channel activity regulates Wnt5 expression in sea urchin larvae, affecting skeletal patterning through spatial control of Wnt5.

Development · May 4, 2023Peer-reviewedDevelopmental Biology

ICAT: A Novel Algorithm to Robustly Identify Cell States Following Perturbations in Single Cell Transcriptomes

Dakota Y. Hawkins, Daniel T. Zuch, James Huth, Nahomie Rodríguez-Sastre, Kelley R. McCutcheon, Abigail Glick, Alexandra T. Lion, Christopher F. Thomas, Abigail E. Descoteaux, William Evan Johnson, Cynthia A. Bradham

ICAT improves identification of cell states after perturbations in single-cell RNA sequencing by using self-supervised feature weighting and control-guided clustering.

Bioinformatics · Apr 22, 2023Peer-reviewedBioinformatics

V-type H+ ATPase Activity is Required for Embryonic Dorsal-Ventral Symmetry Breaking

Daphne Schatzberg, Christopher F. Thomas, Patrick Reidy, Sarah E. Hadyniak, Viktoriya Skidanova, Matthew L. Lawton, Luz Dojer, Shweta Kitchloo, Daniel T. Zuch, Cynthia A. Bradham

This study shows that V-ATPase activity is required for DV symmetry breaking in sea urchin embryos, acting upstream of p38 MAPK and Nodal signaling.

bioRxiv · Oct 18, 2021 · PreprintDevelopmental Biology