Cynthia A. Bradham

This study shows Alizarin Red S causes skeletal and nervous system defects in embryos by inhibiting catalase, leading to increased reactive oxygen species.

This study shows that both PFOA and Gen X, two PFAS compounds, are teratogenic to sea urchin embryos, with Gen X causing more severe developmental effects.

The paper identifies CMTM4 as a gene regulating PMC migration and skeletal patterning in sea urchin embryos through adhesive mechanisms.

The paper shows that voltage-gated sodium channel activity regulates Wnt5 expression in sea urchin larvae, affecting skeletal patterning through spatial control of Wnt5.

ICAT improves identification of cell states after perturbations in single-cell RNA sequencing by using self-supervised feature weighting and control-guided clustering.

The paper uses calcium-binding fluorochromes to study skeletal patterning dynamics in sea urchin embryos, revealing earlier skeletogenesis onset and delayed triradiate formation in perturbed embryos.

This study shows ethanol exposure disrupts skeletal patterning in sea urchin embryos by altering gene expression timing rather than affecting RA or Hh pathways.

This study shows that V-ATPase activity is required for DV symmetry breaking in sea urchin embryos, acting upstream of p38 MAPK and Nodal signaling.

This study analyzes the transcriptome of Lytechinus variegatus during embryonic and larval development, identifying four temporally distinct phases of gene expression.