Abigail E. Descoteaux

This study shows Alizarin Red S causes skeletal and nervous system defects in embryos by inhibiting catalase, leading to increased reactive oxygen species.

This study identifies ciliary trafficking mechanisms and functions of RIC-8 in C. elegans and mammalian cilia, showing its role in chemosensory responses and ciliogenesis.

This study shows that both PFOA and Gen X, two PFAS compounds, are teratogenic to sea urchin embryos, with Gen X causing more severe developmental effects.

The paper identifies CMTM4 as a gene regulating PMC migration and skeletal patterning in sea urchin embryos through adhesive mechanisms.

ICAT improves identification of cell states after perturbations in single-cell RNA sequencing by using self-supervised feature weighting and control-guided clustering.

The paper uses calcium-binding fluorochromes to study skeletal patterning dynamics in sea urchin embryos, revealing earlier skeletogenesis onset and delayed triradiate formation in perturbed embryos.

The paper shows that Mad dephosphorylation at the nuclear envelope creates asymmetry in pMad levels between stem cells and differentiating daughter cells, preventing tumor formation.