Author

W. B. Asher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

A. Faouzi· 1 shared A. Leung· 1 shared A. M. Gutridge· 1 shared B. L. Roth· 1 shared Christopher G Tate· 1 shared D. Provasi· 1 shared D. Sames· 1 shared E. B. Margolis· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. Faouzi

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2 papers

Recent·Most cited

Positive cooperativity enhances coupling of a second G protein to a GPCR dimer

V. Velazhahan, J. Manning, N. Ma, H. D. Taylor, S. Shrestha, Q. Chen, Y. Ren, S. H. McLaughlin, A. Leung, S. Bar, M. Martin, S. Blanchard, W. B. Asher, J. B. Kelley, H. Dohlman, , Christopher G Tate

The paper shows that a second G protein couples with higher affinity to a GPCR dimer than the first, due to conformational stabilization by the first G protein.

bioRxiv · Nov 9, 2026 · PreprintBiochemistry

A novel mitragynine analog with low efficacy mu-opioid receptor agonism displays antinociception with attenuated adverse effects

S. Chakraborty, J. F. Diberto, A. Faouzi, S. M. bernhard, A. M. Gutridge, S. Ramsey, Y. Zhou, D. Provasi, N. Nuthikattu, R. Jilakara, M. Nelson, W. B. Asher, S. O. Eans, L. L. Wilson, S. M. Chintala, , s. majumdar

The paper develops a novel mitragynine analog with reduced mu-opioid receptor efficacy and adverse effects, showing antinociception without respiratory depression or hyperlocomotion.

bioRxiv · Apr 22, 2021Pharmacology & Toxicology