Bottlebrush polymers with sequence-controlled backbones for enhanced oligonucleotide delivery
Yun Wei, Peiru Chen, Mengqi Ren, Deng Li, Jiachen Lin, Tingyu Sun, Yuyan Wang, Shaobo Yang, Christopher Nenopoulos, Christopher Oetheimer, Yao Li, Chenyang Xue, Mona S. Minkara, Ke Zhang
This paper develops sequence-controlled PEG bottlebrush polymers for enhanced oligonucleotide delivery, showing improved cellular uptake and in vivo antisense activity through optimized chemical modifications.
Journal of the American Chemical Society · Nov 27, 2024Peer-reviewedBioengineering