Author

Christopher Situ

University of Toronto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:protein structure· 2 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Joel C. WattsiD· 2 shared Nicholas R. G. SilveriD· 2 shared Alison MaoiD· 1 shared Benedikt FriegiD· 1 shared Bradley T. HymaniD· 1 shared Edward A. FoniD· 1 shared Erica StuartiD· 1 shared G.F. SchroederiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersNeuroscience

Joel C. WattsORCID

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Author profile →

2 papers

Recent·Most cited

Stochastic Misfolding Drives the Emergence of Distinct α-Synuclein Strains

Raphaella W. L. So, Benedikt Frieg, José D. Camino, Christopher Situ, Mark N Metri, Nicholas R. G. Silver, Le yao Li, Alison Mao, Erica Stuart, G.F. Schroeder, Joel C. Watts

This study shows that stochastic misfolding leads to the formation of distinct α-synuclein strains both in vitro and in vivo, resulting in different disease phenotypes.

Neuron · Feb 27, 2026Peer-reviewedNeuroscience

α-Synuclein purification significantly impacts seed amplification assay performance and consistency

Zaid A.M. Al‐Azzawi, Nicholas R. G. Silver, Surabhi Mehra, Simeng Niu, Christopher Situ, Wen Luo, Irina Shlaifer, Martin Ingelsson, Bradley T. Hyman, Jean‐François Trempe, Thomas M. Durcan, Joel C. Watts, Edward A. Fon

This study compares four methods of purifying α-synuclein for seed amplification assays, finding that osmotic shock-purified monomer has the lowest aggregation propensity and best inter-batch reproducibility.

Acta Neuropathologica Communications · Nov 5, 2025Peer-reviewedBiochemistry