Author

Nicholas R. G. Silver

University of TorontoORCID 0000-0002-2199-3123Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 2 Assay:protein structure· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Joel C. WattsiD· 4 shared Martin IngelssoniD· 3 shared Alison MaoiD· 2 shared Bradley T. HymaniD· 2 shared Christopher Situ· 2 shared Erica StuartiD· 2 shared Le yao LiiD· 2 shared Raphaella W. L. SoiD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersNeuroscience

Joel C. WattsORCID

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Author profile →

4 papers

Recent·Most cited

Differently sized soluble α-synuclein species from multiple system atrophy and Lewy body disease brains display different seeding propensities

Silvia Zampar, Y. Mei, Filsy Samuel, Murat Karadag, Iván Martínez-Valbuena, Nicholas R. G. Silver, Gustavo Grimmer, Sonja E. Di Gregorio, Anurag Tandon, Gábor Géza Kovács, Joel C. Watts, Martin Ingelsson

This study compares soluble α-synuclein species from MSA and LBD brains, finding differences in their seeding activity and size distribution.

bioRxiv · Aug 7, 2026 · PreprintNeuroscience

α-Synuclein strain homogeneity in multiple system atrophy clinical subtypes

Heather H. C. Lau, Nicholas R. G. Silver, Surabhi Mehra, Raphaella W. L. So, Le yao Li, Alison Mao, Erica Stuart, Cian Schmitt-Ulms, Bradley T. Hyman, Martin Ingelsson, Joel C. Watts

This study investigates whether distinct α-synuclein strains contribute to clinical subtypes of multiple system atrophy (MSA) and finds no differences in strain properties between MSA-C and MSA-P.

bioRxiv · Jun 10, 2026 · PreprintNeuroscience

Stochastic Misfolding Drives the Emergence of Distinct α-Synuclein Strains

Raphaella W. L. So, Benedikt Frieg, José D. Camino, Christopher Situ, Mark N Metri, Nicholas R. G. Silver, Le yao Li, Alison Mao, Erica Stuart, G.F. Schroeder, Joel C. Watts

This study shows that stochastic misfolding leads to the formation of distinct α-synuclein strains both in vitro and in vivo, resulting in different disease phenotypes.

Neuron · Feb 27, 2026Peer-reviewedNeuroscience

α-Synuclein purification significantly impacts seed amplification assay performance and consistency

Zaid A.M. Al‐Azzawi, Nicholas R. G. Silver, Surabhi Mehra, Simeng Niu, Christopher Situ, Wen Luo, Irina Shlaifer, Martin Ingelsson, Bradley T. Hyman, Jean‐François Trempe, Thomas M. Durcan, Joel C. Watts, Edward A. Fon

This study compares four methods of purifying α-synuclein for seed amplification assays, finding that osmotic shock-purified monomer has the lowest aggregation propensity and best inter-batch reproducibility.

Acta Neuropathologica Communications · Nov 5, 2025Peer-reviewedBiochemistry