Author

Raphaella W. L. So

University of TorontoORCID 0000-0002-6629-0456Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Assay:protein structure· 2 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Joel C. WattsiD· 4 shared Erica StuartiD· 3 shared Alison MaoiD· 2 shared Heather H. C. LauiD· 2 shared Le yao LiiD· 2 shared Nicholas R. G. SilveriD· 2 shared Adriano AguzziiD· 1 shared Aeen Ebrahim Amini· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersNeuroscience

Joel C. WattsORCID

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4 papers

Recent·Most cited

α-Synuclein strain homogeneity in multiple system atrophy clinical subtypes

Heather H. C. Lau, Nicholas R. G. Silver, Surabhi Mehra, Raphaella W. L. So, Le yao Li, Alison Mao, Erica Stuart, Cian Schmitt-Ulms, Bradley T. Hyman, Martin Ingelsson, Joel C. Watts

This study investigates whether distinct α-synuclein strains contribute to clinical subtypes of multiple system atrophy (MSA) and finds no differences in strain properties between MSA-C and MSA-P.

bioRxiv · Jun 10, 2026 · PreprintNeuroscience

Stochastic Misfolding Drives the Emergence of Distinct α-Synuclein Strains

Raphaella W. L. So, Benedikt Frieg, José D. Camino, Christopher Situ, Mark N Metri, Nicholas R. G. Silver, Le yao Li, Alison Mao, Erica Stuart, G.F. Schroeder, Joel C. Watts

This study shows that stochastic misfolding leads to the formation of distinct α-synuclein strains both in vitro and in vivo, resulting in different disease phenotypes.

Neuron · Feb 27, 2026Peer-reviewedNeuroscience

α-Synuclein strain propagation is independent of cellular prion protein expression in transgenic mice

Raphaella W. L. So, Erica Stuart, Aeen Ebrahim Amini, Adriano Aguzzi, Graham L. Collingridge, Joel C. Watts

This study shows that PrPC expression does not significantly affect α-synuclein strain propagation, neuroinvasion, or evolution in transgenic mice.

bioRxiv · Mar 27, 2024 · PreprintNeuroscience

A novel approach to evaluate alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy

Iván Martínez-Valbuena, Naomi P. Visanji, Ain Kim, Heather H. C. Lau, Raphaella W. L. So, Sohaila A. Alshimemeri, Andrew F. Gao, Michael A. Seidman, M. R. Luquín, Joel C. Watts, Anthony Edward Lang, Gábor Géza Kovács

This study introduces a modified Real-Time Quaking-induced Conversion assay to assess alpha-synuclein seeding activity in multiple system atrophy, revealing heterogeneity in seeding behavior across brain regions.

Translational Neurodegeneration · Feb 6, 2022Peer-reviewedNeuroscience