Author

Simeng Niu

Montreal Neurological Institute and Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

Edward A. FoniD· 2 shared Thomas M. DurcaniD· 2 shared Zaid A.M. Al‐AzzawiiD· 2 shared Bradley T. HymaniD· 1 shared Christopher Situ· 1 shared Ghislaine DeyabiD· 1 shared Irina ShlaiferiD· 1 shared Jean‐François TrempeiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBiochemistry

Edward A. FonORCID

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2 papers

Recent·Most cited

α-Synuclein purification significantly impacts seed amplification assay performance and consistency

Zaid A.M. Al‐Azzawi, Nicholas R. G. Silver, Surabhi Mehra, Simeng Niu, Christopher Situ, Wen Luo, Irina Shlaifer, Martin Ingelsson, Bradley T. Hyman, Jean‐François Trempe, Thomas M. Durcan, Joel C. Watts, Edward A. Fon

This study compares four methods of purifying α-synuclein for seed amplification assays, finding that osmotic shock-purified monomer has the lowest aggregation propensity and best inter-batch reproducibility.

Acta Neuropathologica Communications · Nov 5, 2025Peer-reviewedBiochemistry

Midbrain organoids with an SNCA gene triplication display dopamine-dependent alterations in network activity

Ghislaine Deyab, Rhalena A. Thomas, Xue Er Ding, Jialun Li, Julien Sirois, Zaid A.M. Al‐Azzawi, Simeng Niu, Thomas M. Durcan, Edward A. Fon

This study shows that midbrain organoids with SNCA gene triplication exhibit PD-like neural activity changes, which can be reversed by dopamine agonists.

bioRxiv · Apr 23, 2025 · PreprintNeuroscience