Paulo R. Jannig

Decoding human placental cellular and molecular responses to maternal obesity and fetal growth

The paper identifies placental cell-type-specific transcriptional responses to maternal obesity and fetal growth using single-nucleus RNAseq and microfluidic organoids.

Small-molecule targeting MuRF1 protects against denervation-induced diaphragmatic dysfunction: Underlying molecular mechanisms

This study shows that MyoMed-205, a small-molecule targeting MuRF1, prevents diaphragm atrophy and dysfunction after 12 hours of unilateral denervation in rats by enhancing muscle structure, function, and reducing fibrosis.

The mitochondrial mRNA stabilizing protein, SLIRP, regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms

This study identifies SLIRP as a mitochondrial mRNA stabilizing protein that regulates mitochondrial structure and respiration in skeletal muscle, with exercise improving mitochondrial function through increased mitoribosome capacity.

The 24-Hour Time Course of Integrated Molecular Responses to Resistance Exercise in Human Skeletal Muscle Implicates MYC as a Hypertrophic Regulator That is Sufficient for Growth

This study maps the 24-hour molecular response to resistance exercise in human muscle, identifying MYC as a key regulator of hypertrophy and mRNA levels.

PGC-1α isoforms coordinate to balance hepatic metabolism and apoptosis in inflammatory environments

The paper investigates how different PGC-1α isoforms regulate hepatic metabolism and apoptosis in response to inflammation, identifying distinct roles for PGC-11 and PGC-14.