Cerebral Small Vessel Disease genetic determinant TRIM47 controls brain homeostasis via the NRF2 antioxidant system
Cécile Duplàa, Valentin Delobel, Romain Boulestreau, Sébastien Rubin, Juliette Vaurs, Béatrice Jaspard‐Vinassa, Muriel Busson, Cloé Combrouze, Carole Proust, Jean‐Luc Morel, Bruno Bontempi, Aniket Mishra, Stéphanie Debette, Thierry Couffinhal, Claire R. Peghaire
This study identifies TRIM47 as a genetic determinant of cerebral small vessel disease, showing it regulates brain homeostasis through the NRF2 antioxidant pathway by stabilizing NRF2 protein levels.
bioRxiv · Oct 8, 2024 · PreprintNeuroscience