Proteomic and metabolic profiling reveals APOE4-dependent shifts in whole brain, neuronal, and astrocytic mitochondrial function and glycolysis
Colton R Lysaker, Chelsea N. Johnson, Vivien Csikós, Edziu Franczak, Maggie N. Benson, Caleb A. Gilmore, Cole J. Birky, Xin C. Davis, Colin S. McCoin, Keith P. Smith, Patrycja Puchalska, Peter A. Crawford, Chad M Slawson, John P. Thyfault, Paige C. Geiger, , Heather Wilkins
This study identifies APOE4-dependent metabolic changes in brain cells, showing increased glycolysis and mitochondrial dysfunction in neurons and astrocytes.
bioRxiv · Jun 15, 2025 · PreprintNeuroscience