Alapakkam P. Sampath

Conservation of cis-regulatory codes over half a billion years of evolution

The paper shows that cis-regulatory codes in retinal cell classes are highly conserved across vertebrates despite extensive enhancer turnover.

Late gene therapy limits the restoration of retinal function in a mouse model of retinitis pigmentosa

This study shows that gene therapy for retinitis pigmentosa is most effective when administered before 50% rod loss, as later treatment fails to restore normal retinal function.

Cones and Cone Pathways Remain Functional in Advanced Retinal Degeneration

The paper shows that cones and their retinal pathways remain functional in advanced retinal degeneration, even as cones lose their outer-segment structures.

Robust cone-mediated signaling persists late into rod photoreceptor degeneration

This study shows that cone-mediated signaling remains robust in retinal ganglion cells despite rod photoreceptor degeneration, suggesting gene therapies may still effectively preserve vision.

Activation of rod input in a model of retinal degeneration reverses retinal remodeling and induces formation of normal synapses, circuitry and visual signaling in the adult retina

This study shows that activating rod input in a retinal degeneration model restores synaptic structure, circuitry, and visual signaling in adult mice.