An aging-sensitive compensatory secretory phospholipase that confers neuroprotection and cognitive resilience
Cinzia Vicidomini, Travis D. Goode, Kathleen M. McAvoy, Ruilin Yu, Conor H. Beveridge, Sanjay N. Iyer, Matheus B. Victor, Noelle Leary, Liam Evans, Michael J. Steinbaugh, Zon Weng Lai, Marina C. Lyon, Manuel Rico F.S Silvestre, Gracia M. Bonilla, Ruslan I. Sadreyev, , Amar Sahay
This study identifies Pla2g2f as a neuroprotective factor that maintains lipid homeostasis and mitigates aging-associated cognitive decline in a mouse model of Alzheimer's disease.
bioRxiv · Jul 26, 2024 · PreprintNeuroscience