Author

Noelle Leary

Massachusetts Institute of Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 5

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:differential expression· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Organism:mouse· 2

Frequent Co-Authors

Li‐Huei TsaiiD· 5 shared Matheus B. VictoriD· 4 shared Aine Ni Scannail· 3 shared Gwyneth WelchiD· 3 shared Liwang Liu· 3 shared M KellisiD· 3 shared Carles A. BoixiD· 2 shared Djuna Katrina von MaydelliD· 2 shared

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2022-2025 · peak 2/yr

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10 top collaborators · 45 mutual co-author links

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5 shared papersNeuroscience

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5 papers

Recent·Most cited

Compensatory Plasticity Defines a Vulnerable Neuronal State in Alzheimers Disease with Psychosis

Matheus B. Victor, Na Sun, Kyriaki Galani, Noelle Leary, Yosuke Tanigawa, Aine Ni Scannail, Li‐Lun Ho, Shaniah Prosper, Liwang Liu, Julia Kofler, Robert A. Sweet, Li‐Huei Tsai, M Kellis

The paper identifies transcriptional changes in upper-layer cortical pyramidal neurons in Alzheimer's disease with psychosis, linking them to network dysfunction and vulnerability.

bioRxiv · Apr 30, 2025 · PreprintNeuroscience

An aging-sensitive compensatory secretory phospholipase that confers neuroprotection and cognitive resilience

Cinzia Vicidomini, Travis D. Goode, Kathleen M. McAvoy, Ruilin Yu, Conor H. Beveridge, Sanjay N. Iyer, Matheus B. Victor, Noelle Leary, Liam Evans, Michael J. Steinbaugh, Zon Weng Lai, Marina C. Lyon, Manuel Rico F.S Silvestre, Gracia M. Bonilla, Ruslan I. Sadreyev, , Amar Sahay

This study identifies Pla2g2f as a neuroprotective factor that maintains lipid homeostasis and mitigates aging-associated cognitive decline in a mouse model of Alzheimer's disease.

bioRxiv · Jul 26, 2024 · PreprintNeuroscience

ABCA7 Loss-of-Function Variants Impact Phosphatidylcholine Metabolism in the Human Brain

Djuna Katrina von Maydell, Shannon Wright, Ping‐Chieh Pao, Colin Staab, Oisín King, Andrea Spitaleri, Julia Maeve Bonner, Liwang Liu, Chung Jong Yu, Ching-Chi Chiu, Daniel Leible, Aine Ni Scannail, Mingpei Li, Carles A. Boix, Hansruedi Mathys, , Li‐Huei Tsai

This study identifies ABCA7 loss-of-function variants' impact on phosphatidylcholine metabolism in human neurons and shows CDP-choline can reverse these effects.

bioRxiv · Sep 5, 2023 · PreprintNeuroscience

Neurons burdened by DNA double strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration.

Gwyneth Welch, Carles A. Boix, Eloi Schmauch, José Dávila-Velderrain, Matheus B. Victor, Vishnu Dileep, P. Lorenzo Bozzelli, Qiao Su, Jemmie Cheng, Audrey Lee, Noelle Leary, Andreas R. Pfenning, M Kellis, Li‐Huei Tsai

The paper identifies that DNA double strand breaks in neurons activate immune pathways, leading to microglia activation in neurodegeneration.

Science Advances · Sep 28, 2022Peer-reviewedNeuroscience

Lipid Accumulation Induced by APOE4 Impairs Microglial Surveillance of Neuronal-Network Activity

Matheus B. Victor, Noelle Leary, Xochitl Luna, Hiruy S. Meharena, Aine Ni Scannail, P. Lorenzo Bozzelli, George Samaan, Mitchell H. Murdock, Djuna Katrina von Maydell, Audrey H. Effenberger, Oyku Cerit, Hsin-Lan Wen, Liwang Liu, Gwyneth Welch, Julia Maeve Bonner, Li‐Huei Tsai

This study shows that APOE4 in microglia causes lipid accumulation, impairing their ability to monitor neuronal activity and leading to disrupted neuronal network function.

Cell stem cell · Aug 1, 2022Peer-reviewedNeuroscience