Neutral lipid processing in glia is sexually dimorphic and promotes sleep through diacylglycerol catabolism
Elana S. Pyfrom, Connor H. Beveridge, Paula R. Haynes, Vishal A. Kanigicherla, Caitlin E. Randolph, Paula Carvalho Costa, Seble G. Negatu, Sanjay N. Iyer, Samantha L. Killiany, Zhifeng Yue, Erick Astacio, Katherine A. Walker, Kiet N. Luu, Pavel Pivarshev, Kellie A. Jurado, , Amita Sehgal
The paper identifies sex-specific lipid differences in Drosophila neurons and glia and links glial diacylglycerol catabolism to sleep promotion.
bioRxiv · Sep 10, 2025 · PreprintNeuroscience