Human Neonatal MR1T Cells Have Diverse TCR Usage, are Less Cytotoxic and are Unable to Respond to Many Common Childhood Pathogens.
Dylan C. Kain, Wael Awad, GW McElfresh, Meghan E. Cansler, Gwendolyn M. Swarbrick, Kean Chan Yew Poa, Conor McNeice, Gregory J. Boggy, Katherine H. Rott, Megan D. Null, David Michael Lewinsohn, Jamie Rossjohn, Benjamin N. Bimber, Deborah A. Lewinsohn
This study compares neonatal and adult MR1T cells, finding neonatal cells have diverse TCR usage, reduced cytotoxicity, and limited pathogen recognition.
bioRxiv · Mar 17, 2025 · PreprintImmunology