Dylan C. Kain

This study maps human pulmonary T-cell immunity across TB infection/disease using single-cell transcriptomics and functional T-cell cloning, identifying protective immune features and a platform for TB vaccine development.

This study shows that IL-23 and TCR stimulation together are needed for lung MAIT cells to produce IL-17A, with distinct transcriptional changes observed.

This study examines how BCG vaccination at birth affects MR1T cell TCR usage and function in infants, finding increased type I interferon response and a TCR cluster enriched in vaccinated infants.

This study compares neonatal and adult MR1T cells, finding neonatal cells have diverse TCR usage, reduced cytotoxicity, and limited pathogen recognition.