Deborah A. Lewinsohn

The paper shows human memory CD4+ T cells recognize both Mtb-infected and bystander macrophages, with some TCRs specifically recognizing infected cells.

This study maps human pulmonary T-cell immunity across TB infection/disease using single-cell transcriptomics and functional T-cell cloning, identifying protective immune features and a platform for TB vaccine development.

This study shows that IL-23 and TCR stimulation together are needed for lung MAIT cells to produce IL-17A, with distinct transcriptional changes observed.

This study examines how BCG vaccination at birth affects MR1T cell TCR usage and function in infants, finding increased type I interferon response and a TCR cluster enriched in vaccinated infants.

The paper identifies distinct antibody-based signatures and functionalities in latent and active pediatric tuberculosis, highlighting differences in humoral immune responses that may inform diagnostic and therapeutic strategies.

Deleting early riboflavin genes (ribA2 in both species, ribG in M. smegmatis) sharply reduced MAIT cell activation, while ribH deletion raised recognition of M. tuberculosis only.

The paper identifies two distinct cytokine response clusters in healthcare workers resistant to Mtb infection despite exposure, using cytokine profiling and clustering analysis.

This study compares neonatal and adult MR1T cells, finding neonatal cells have diverse TCR usage, reduced cytotoxicity, and limited pathogen recognition.

This study investigates riboflavin biosynthesis and utilization in mycobacteria by creating conditional knockdowns and analyzing their impact on viability and MAIT cell recognition.