Author

Wael Awad

Monash UniversityORCID 0000-0002-7597-2133Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Jamie RossjohniD· 3 shared Nicholas A. GherardiniD· 2 shared Adam P. UldrichiD· 1 shared Alexandra Jane CorbettiD· 1 shared Alexis Perez‐GonzaleziD· 1 shared Anthony Wayne PurcelliD· 1 shared Benjamin N. BimberiD· 1 shared Calvin XuiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersImmunology

Jamie RossjohnORCID

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Author profile →

3 papers

Recent·Most cited

Specific targeting of MR1-antigen complexes using nanobodies

Hisham S. Hussain, Samuel J. Redmond, Wael Awad, Calvin Xu, Caroline Soliman, Huimeng Wang, Yuyang Zhang, Lisa Ciacchi, Alexis Perez‐Gonzalez, Jeffrey Y. W. Mak, David P. Fairlie, James McCluskey, Alexandra Jane Corbett, Adam P. Uldrich, Jamie Rossjohn, , Nicholas A. Gherardin

The paper develops a nanobody targeting MR1-5-OP-RU complexes and demonstrates its ability to modulate MAIT cell responses and act as a bispecific engager.

Science Immunology · Sep 25, 2026Peer-reviewedImmunology

The antigen presenting molecule MR1 binds riboflavin catabolites

Mohamed R. Abdelaal, Jieru Deng, Mitchell P. McInerney, Emi Ito, Anthony Wayne Purcell, Sho Yamasaki, Jóse A. Villadangos, Hamish E. G. McWilliam, Nicholas A. Gherardin, Jamie Rossjohn, Wael Awad

This study identifies riboflavin catabolites that bind MR1, reduce its cell surface expression, and inhibit MAIT cell activation.

bioRxiv · Jul 20, 2025 · PreprintBiochemistry

Human Neonatal MR1T Cells Have Diverse TCR Usage, are Less Cytotoxic and are Unable to Respond to Many Common Childhood Pathogens.

Dylan C. Kain, Wael Awad, GW McElfresh, Meghan E. Cansler, Gwendolyn M. Swarbrick, Kean Chan Yew Poa, Conor McNeice, Gregory J. Boggy, Katherine H. Rott, Megan D. Null, David Michael Lewinsohn, Jamie Rossjohn, Benjamin N. Bimber, Deborah A. Lewinsohn

This study compares neonatal and adult MR1T cells, finding neonatal cells have diverse TCR usage, reduced cytotoxicity, and limited pathogen recognition.

bioRxiv · Mar 17, 2025 · PreprintImmunology