Pneumococcal H2O2 Reshapes Mitochondrial Function and Reprograms Host Cell Metabolism
Anna Scasny, Babek Alibayov, Ngoc Hoang, Ana G. Jop Vidal, Kenichi Takeshita, Consuelo Bautista, Eva Bengtén, Antonino Baez, Wei Li, Jonathan P. Hosler, Kurt Warncke, Kristin Shirey Edwards, Jorge Eugenio Vidal
This study shows pneumococcus-derived H2O2 disrupts host TCA cycle and induces a Warburg-like metabolic shift in lung epithelial cells, enhancing bacterial survival.
bioRxiv · May 22, 2025 · PreprintMicrobiology