MicrobiologybioRxivPreprint
Lactate Oxidase (LctO) Acts as a Metabolic Checkpoint Restraining Streptococcus pneumoniae Invasion of Respiratory Epithelial Barriers
DOI 10.64898/2026.07.15.738724
Author
Jorge Eugenio Vidal
University of Mississippi Medical CenterORCID 0000-0003-0573-5658Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2025-2026 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 27 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship4 papers
Recent·Most cited
- ImmunologybioRxivPreprint
A pan-serotype human monoclonal antibody protects against pneumococcal infection by targeting multiple choline binding domain proteins
Anna L. McCormick, Behrouz Ghazi Esfahani, Caroline Katherine Page…·Jarrod J. Mousa
This paper identifies a human monoclonal antibody that protects against multiple pneumococcal serotypes by targeting conserved choline-binding domain proteins.
DOI 10.64898/2026.05.28.728567 - MicrobiologybioRxivPreprint
Metabolic Rewiring at the Pyruvate Node Drives Severe Pneumonia and T-Cell Suppression in Serotype 3 Streptococcus pneumoniae Infection
Kenichi Takeshita, Ana G. Jop Vidal, Jorge Eugenio Vidal
This study identifies a metabolic pathway in Streptococcus pneumoniae that drives pneumonia and immune evasion through oxygen-sensitive growth and membrane bleb formation.
DOI 10.64898/2026.02.13.705843 - MicrobiologybioRxivPreprint
Pneumococcal H2O2 Reshapes Mitochondrial Function and Reprograms Host Cell Metabolism
Anna Scasny, Babek Alibayov, Ngoc Hoang…·Jorge Eugenio Vidal
This study shows pneumococcus-derived H2O2 disrupts host TCA cycle and induces a Warburg-like metabolic shift in lung epithelial cells, enhancing bacterial survival.
DOI 10.1101/2025.05.22.655446