Kenichi Takeshita

This study identifies a metabolic pathway in Streptococcus pneumoniae that drives pneumonia and immune evasion through oxygen-sensitive growth and membrane bleb formation.

This study shows that heme from oxidized hemoglobin promotes the selection of encapsulated Streptococcus pneumoniae in the lungs, linking oxidative stress to pneumococcal pneumonia pathogenesis.

This study shows pneumococcus-derived H2O2 disrupts host TCA cycle and induces a Warburg-like metabolic shift in lung epithelial cells, enhancing bacterial survival.