A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent
Misha Klein, Arnab Das, Subhas Chandra Bera, Thomas K. Anderson, Dana Kocíncová, Hery W. Lee, Bing Wang, Flavia Stal Papini, John C. Marecki, Jamie J. Arnold, Craig E Cameron, Kevin D. Raney, Irina Artsimovitch, Matthias Götte, Robert N. Kirchdoerfer, , David Dulin
The paper shows that the SARS-CoV-2 polymerase core RTC undergoes a conformational change after RNA binding to become elongation-competent, which is essential for viral RNA synthesis.
Nucleic Acids Research · May 21, 2025Peer-reviewedBiophysics