KDM6A Regulates Immune Response Genes in Multiple Myeloma
Daphné Dupéré-Richer, Alberto Riva, Sayantan Maji, Benjamin G. Barwick, Heidi L. Casellas Román, Amin Sobh, Gabrielle Quickstad, Jianping Li, Umasankar De, Crissandra Piper, Marta Kulis, Teresa Ezponda, José Ignacio Martín-Subero, Giovanni Tonon, Weizhou Zhang, , Jonathan D. Licht
This study shows KDM6A regulates immune response genes in multiple myeloma by activating NLRC5 and CIITA, and its loss reduces MHC expression, which can be reversed by HDAC3 inhibitors.
Blood · Jul 24, 2024Peer-reviewedCancer Biology