Development of Potent, Selective cPLA2 Inhibitors for Targeting Neuroinflammation in Alzheimer's Disease and Other Neurodegenerative Disorders
Anastasiia Sadybekov, Marlon Vincent V. Duro, Shaowei Wang, Brandon Ebright, Dante Dikeman, Cristelle Hugo, Bilal E. Kerman, Qiu-Lan Ma, Antonina L. Nazarova, Arman A. Sadybekov, Isaac Asante, Stan G. Louie, Vsevolod Katritch, Hussein N. Yassine
This study identifies a potent cPLA2 inhibitor, BRI-50460, that modulates neuroinflammation and lipid homeostasis in Alzheimer's disease models.
npj Drug Discovery. · Jan 7, 2026Peer-reviewedNeuroscience