Shaowei Wang

TOMM40 suppression promotes neuronal cholesterol imbalance and molecular and behavioral phenotypes of Alzheimer's disease

This study shows that TOMM40 suppression leads to cholesterol imbalance and AD-like molecular and behavioral changes in mice and human neurons.

Evidence for cPLA2 activation in Alzheimer's Disease Synaptic Pathology

This study shows cPLA2 overactivation is linked to synaptic loss and cognitive decline in Alzheimer's disease through increased eicosanoids and altered synaptic marker interactions.

Development of Potent, Selective cPLA2 Inhibitors for Targeting Neuroinflammation in Alzheimer's Disease and Other Neurodegenerative Disorders

This study identifies a potent cPLA2 inhibitor, BRI-50460, that modulates neuroinflammation and lipid homeostasis in Alzheimer's disease models.

Effect of the S2' site cleavage on SARS-CoV-2 spike

The paper reports a cryo-EM structure of the S2 fragment of SARS-CoV-2 after S2 cleavage, showing it represents a late fusion intermediate, and shows that S2 cleavage accelerates membrane fusion.

Microglia States are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer's Disease

This study identifies microglia as key contributors to senescence in Alzheimer's disease, linking cholesterol dysregulation to senescence pathologies through transcriptomic analysis of multiple datasets.