Targeting the translation initiation complex in therapy-resistant and metastatic melanoma
Yongmei Feng, Ximena Diaz-Olea, Xiurong Ke, Mariia Radaeva, Mehdi Amiri, Hyunjeong Joo, Maryam Jafari, Hyungsoo Kim, Aniruddha J. Deshpande, Steven H. Olson, Predrag Jovanović, Yangqi Su, Aagam S. Shah, Ian Pass, Qiyun Deng, , Ze’ev A. Ronai
This study identifies M19-6 as a small molecule that disrupts the eIF4F complex, reducing melanoma growth and metastasis while sparing melanocytes.
bioRxiv · Nov 20, 2024 · PreprintCancer Biology