Author

Hyunjeong Joo

Cedars-Sinai Medical CenterORCID 0000-0001-5872-5686Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:human· 3 Approach:statistical model· 3 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Research Focus:differential expression· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Eytan RuppiniD· 3 shared Hyungsoo KimiD· 3 shared Ze’ev A. RonaiiD· 3 shared Arashdeep SinghiD· 2 shared Chi‐Ping DayiD· 2 shared Lipika R. PaliD· 2 shared Omid HamidiD· 2 shared Saugato Rahman DhrubaiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Eytan RuppinORCID

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3 papers

Recent·Most cited

Transient Splicing-Associated Isoform Remodeling Defines Early MAPKi Resistance Adaptation in Melanoma

Sumit Mukherjee, Arashdeep Singh, Sumeet Patiyal, Hyunjeong Joo, Hyungsoo Kim, Lipika R. Pal, Kun Wang, Chi‐Ping Day, Ze’ev A. Ronai, Eytan Ruppin, Sridhar S. Hannenhalli

The paper identifies transient isoform remodeling as a key mechanism in early MAPKi resistance in melanoma, showing it is distinct from gene expression changes and linked to splicing regulators and developmental pathways.

bioRxiv · Oct 28, 2026 · PreprintCancer Biology

Pan-cancer prediction of tumor immune activation and response to immune checkpoint blockade from tumor transcriptomics and histopathology

Sumit Mukherjee, Sumeet Patiyal, Lipika R. Pal, Keluo Yao, Tiangen Chang, Sumona Biswas, Saugato Rahman Dhruba, Amos Stemmer, Arashdeep Singh, Abbas Yousefi-Rad, Tien-Hua Chen, Binbin Wang, Denis Marino, Wonwoo Shon, Yuan Yuan, , Eytan Ruppin

This paper introduces TIME_ACT, a transcriptomic signature predicting immune checkpoint blockade response across cancers, validated using histopathology and multiple cohorts.

bioRxiv · Jun 27, 2025 · PreprintCancer Biology

Targeting the translation initiation complex in therapy-resistant and metastatic melanoma

Yongmei Feng, Ximena Diaz-Olea, Xiurong Ke, Mariia Radaeva, Mehdi Amiri, Hyunjeong Joo, Maryam Jafari, Hyungsoo Kim, Aniruddha J. Deshpande, Steven H. Olson, Predrag Jovanović, Yangqi Su, Aagam S. Shah, Ian Pass, Qiyun Deng, , Ze’ev A. Ronai

This study identifies M19-6 as a small molecule that disrupts the eIF4F complex, reducing melanoma growth and metastasis while sparing melanocytes.

bioRxiv · Nov 20, 2024 · PreprintCancer Biology