Author

Qiyun Deng

Institut du cancer Rosalind & Morris GoodmanORCID 0000-0002-6900-2587Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Mehdi AmiriiD· 3 shared Nahum SonenbergiD· 3 shared Aagam S. ShahiD· 1 shared Alfredo MolinoloiD· 1 shared Anastasija Ana Piric· 1 shared Andia Moshari· 1 shared Aniruddha J. DeshpandeiD· 1 shared Antonis E. KoromilasiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCancer Biology

Mehdi AmiriORCID

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3 papers

Recent·Most cited

A therapeutic vulnerability linking MNK1/2 inhibition and G1/S cyclin-dependent kinase blockade in triple-negative breast cancer

Qiyun Deng, Mehdi Amiri, Andia Moshari, Binadi Diddeniya, Parastoo Akbarnia, Anastasija Ana Piric, Érika Prando Munhoz, Yasaman Bagherian, Zilan Li, Michael A. Bellucci, Niaz Mahmood, Michaël Pollak, Sidong Huang, Nahum Sonenberg

This study identifies a synergistic therapeutic effect of combining MNK1/2 inhibition with G1/S CDK blockade in triple-negative breast cancer.

bioRxiv · Sep 16, 2026 · PreprintCancer Biology

eIF2B Selectively Anchors and Activates Mutant KRAS

Hyungdong Kim, Shiqi Diao, Kwang‐Jin Cho, Hyun-Ro Lee, Junchen Liu, Pascal F. Egea, Tatu Pantsar, Milla Kurki, Nour Ghaddar, Shuo Wang, Jia Yi Zou, Mehdi Amiri, Ritchel B. Gannaban, John F. Hancock, Kylie M. Rice, , Antonis E. Koromilas

This paper shows eIF2B activates mutant KRAS by forming a complex with SOS at the plasma membrane and regulating glycosphingolipid biosynthesis.

bioRxiv · Nov 10, 2025 · PreprintCancer Biology

Targeting the translation initiation complex in therapy-resistant and metastatic melanoma

Yongmei Feng, Ximena Diaz-Olea, Xiurong Ke, Mariia Radaeva, Mehdi Amiri, Hyunjeong Joo, Maryam Jafari, Hyungsoo Kim, Aniruddha J. Deshpande, Steven H. Olson, Predrag Jovanović, Yangqi Su, Aagam S. Shah, Ian Pass, Qiyun Deng, , Ze’ev A. Ronai

This study identifies M19-6 as a small molecule that disrupts the eIF4F complex, reducing melanoma growth and metastasis while sparing melanocytes.

bioRxiv · Nov 20, 2024 · PreprintCancer Biology