Author

Ole Wiskow

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Research Focus:gene regulatory network inference· 1 Assay:imaging· 1

Frequent Co-Authors

Kevin C. EgganiD· 3 shared Bruno BoiviniD· 2 shared Clifford J. WoolfiD· 2 shared Devlin FrostiD· 2 shared Xuan HuangiD· 2 shared Adam E. CoheniD· 1 shared Alyssa Grantham· 1 shared Anne Elizabeth CarpenteriD· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersNeuroscience

Kevin C. EgganORCID

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Author profile →

3 papers

Recent·Most cited

Downregulation of the silent potassium channel Kv8.1 increases ALS motor neuron vulnerability

Xuan Huang, Seungkyu Lee, Riki Kawaguchi, Ole Wiskow, Sulagna Dia Ghosh, Devlin Frost, Laura Perrault, Roshan Pandey, Kuchuan Chen, Joseph R. Klim, Bruno Boivin, Crystal Hermawan, Kenneth J. Livak, Dan H. Geschwind, Brian J. Wainger, , Clifford J. Woolf

The paper shows that reduced Kv8.1 expression in ALS motor neurons with SOD1(A4V) and C9orf72 mutations increases vulnerability to cell death by affecting metabolism and transport pathways.

bioRxiv · May 7, 2023 · PreprintNeuroscience

A Multiparametric Activity Profiling Platform for Neuron Disease Phenotyping and Drug Screening

Bruno Boivin, Kasper C. D. Roet, Xuan Huang, Kyle W. Karhohs, Mohammad Hossein Rohban, Jackson Sandoe, Ole Wiskow, Rie K. Maeda, Alyssa Grantham, Mary Kate Dornon, Jenny Shao, Devlin Frost, Dylan S. Baker, Kevin C. Eggan, Anne Elizabeth Carpenter, Clifford J. Woolf

The paper introduces a cloud-based platform for analyzing calcium activity in motor neurons to identify compounds that reverse disease phenotypes in amyotrophic lateral sclerosis.

Molecular Biology of the Cell · Dec 15, 2021Peer-reviewedNeuroscience

All-optical electrophysiology for high-throughput functional characterization of human iPSC-derived motor neuron model of ALS

Evangelos Kiskinis, Joel M. Kralj, Peng Zou, Eli N. Weinstein, Hongkang Zhang, Konstantinos Tsioras, Ole Wiskow, Juan Alberto Ortega, Kevin C. Eggan, Adam E. Cohen

The paper introduces an all-optical electrophysiology method called Optopatch to functionally characterize human iPSC-derived motor neurons in ALS models, finding altered electrophysiological properties in SOD1 A4V mutants.

Stem Cell Reports · May 17, 2018Peer-reviewedNeuroscience