Author

D. A. LaBreck

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

A. Natarajan· 1 shared D. B. Sykes· 1 shared D. Price· 1 shared D. Wang· 1 shared J. F. Santana· 1 shared J. R. Mallareddy· 1 shared K. Mehla· 1 shared M. A. Hollingsworth· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

A. Natarajan

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1 paper

Recent·Most cited

DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation

N. J. Mullen, S. K. Shukla, R. Thakur, S. S. Kollala, D. Wang, N. Chaika, J. F. Santana, W. R. Miklavcic, D. A. LaBreck, J. R. Mallareddy, D. Price, A. Natarajan, K. Mehla, D. B. Sykes, M. A. Hollingsworth, P. K. Singh

This study shows DHODH inhibition enhances immune checkpoint blockade by increasing cancer cell antigen presentation through pyrimidine depletion and P-TEFb-mediated RNA polymerase II elongation.

bioRxiv · Apr 3, 2023Cancer Biology