DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation
N. J. Mullen, S. K. Shukla, R. Thakur, S. S. Kollala, D. Wang, N. Chaika, J. F. Santana, W. R. Miklavcic, D. A. LaBreck, J. R. Mallareddy, D. Price, A. Natarajan, K. Mehla, D. B. Sykes, M. A. Hollingsworth, P. K. Singh
This study shows DHODH inhibition enhances immune checkpoint blockade by increasing cancer cell antigen presentation through pyrimidine depletion and P-TEFb-mediated RNA polymerase II elongation.
bioRxiv · Apr 3, 2023Cancer Biology