Author

N. Chaika

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

P. K. Singh· 2 shared A. Natarajan· 1 shared B. Chen· 1 shared C. V. Leiton· 1 shared C.-H. Pan· 1 shared D. A. LaBreck· 1 shared D. B. Sykes· 1 shared D. Price· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

P. K. Singh

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2 papers

Recent·Most cited

DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation

N. J. Mullen, S. K. Shukla, R. Thakur, S. S. Kollala, D. Wang, N. Chaika, J. F. Santana, W. R. Miklavcic, D. A. LaBreck, J. R. Mallareddy, D. Price, A. Natarajan, K. Mehla, D. B. Sykes, M. A. Hollingsworth, P. K. Singh

This study shows DHODH inhibition enhances immune checkpoint blockade by increasing cancer cell antigen presentation through pyrimidine depletion and P-TEFb-mediated RNA polymerase II elongation.

bioRxiv · Apr 3, 2023Cancer Biology

Targeting keratin 17-mediated reprogramming of de novo pyrimidine biosynthesis to overcome chemoresistance in pancreatic cancer

C.-H. Pan, N. Chaika, R. Tseng, M. A. Siraj, B. Chen, K. L. Donnelly, M. Horowitz, C. V. Leiton, S. Chowdhury, L. Roa-Pena, L. Oblein, N. Marchenko, P. K. Singh, K. R. Shroyer, L. F. Escobar-Hoyos

This study identifies K17-mediated pyrimidine biosynthesis as a mechanism of chemoresistance in PDAC and shows that targeting DHODH with Brequinar enhances the efficacy of chemotherapy.

bioRxiv · Aug 24, 2022Cancer Biology