Author

D. A. Moustafa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

J. B. Goldberg· 4 shared A. DiGiandomenico· 1 shared A. Repele· 1 shared B. L. Bassler· 1 shared C. D. Thouvenel· 1 shared C. Dean· 1 shared C. Sternberg· 1 shared D. J. Rawlings· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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4 shared papersMicrobiology

J. B. Goldberg

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4 papers

Recent·Most cited

Serotype switching in Pseudomonas aeruginosa ST111 enhances adhesion and virulence

M. Anbo, M. A. Lubna, D. A. Moustafa, T. O. Paiva, L. Serioli, K. Zor, C. Sternberg, K. Jeannot, Y. F. Dufrene, J. B. Goldberg, L. Jelsbak

This study shows that serotype switching in Pseudomonas aeruginosa ST111 from O4 to O12 enhances adhesion, motility, and virulence in murine pneumonia.

bioRxiv · Apr 26, 2024 · PreprintMicrobiology

Monoclonal antibodies derived from B cells in subjects with cystic fibrosis reduce Pseudomonas aeruginosa burden in mice

M. Hale, K. K. Takehara, C. D. Thouvenel, D. A. Moustafa, A. Repele, M. F. Fontana, J. Netland, S. McNamara, R. L. Gibson, J. B. Goldberg, D. J. Rawlings, M. Pepper

The paper isolates PcrV-specific B cells from cystic fibrosis patients and generates monoclonal antibodies that reduce Pseudomonas aeruginosa burden in mice.

bioRxiv · Apr 8, 2024 · PreprintImmunology

Efficacy of a Pseudomonas aeruginosa Serogroup O9 Vaccine

D. A. Moustafa, A. DiGiandomenico, V. Raghuram, M. Schulman, J. Scarff, M. R. Davis, J. J. Varga, C. Dean, J. B. Goldberg

This study develops a vaccine against Pseudomonas aeruginosa serogroup O9 using an attenuated Salmonella strain expressing the O9 LPS, showing it induces protective immunity in mice.

bioRxiv · Jul 13, 2023 · PreprintMicrobiology

The PqsE active site as a target for small molecule antimicrobial agents against Pseudomonas aeruginosa

I. R. Taylor, P. D. Jeffrey, D. A. Moustafa, J. B. Goldberg, B. L. Bassler

This paper shows that disrupting the PqsE-RhlR interaction reduces P. aeruginosa infection in mice and presents new molecules targeting the PqsE active site.

bioRxiv · Apr 21, 2022Microbiology