J. B. Goldberg

De novo mutations mediate phenotypic switching in an opportunistic human lung pathogen

This study shows that de novo mutations in Burkholderia dolosa cause phenotypic switching, with O-antigen loss increasing immune cell uptake but reducing lung competitiveness, depending on infection duration and tissue localization.

Experimentally Evolved Staphylococcus aureus Survives in the Presence of Pseudomonas aeruginosa by Acquiring Mutations in the Amino Acid Transporter, GltT

This study identifies mutations in the amino acid transporter GltT that enable Staphylococcus aureus to survive in the presence of Pseudomonas aeruginosa through altered glutamate metabolism.

Efficacy of a Pseudomonas aeruginosa Serogroup O9 Vaccine

This study develops a vaccine against Pseudomonas aeruginosa serogroup O9 using an attenuated Salmonella strain expressing the O9 LPS, showing it induces protective immunity in mice.

The Type VI Secretion System of the Emerging Pathogen Stenotrophomonas maltophilia has Antibacterial Properties

This study shows that the T6SS of S. maltophilia can eliminate other bacteria and enhance its competitive fitness against Pseudomonas aeruginosa.

The PqsE active site as a target for small molecule antimicrobial agents against Pseudomonas aeruginosa

This paper shows that disrupting the PqsE-RhlR interaction reduces P. aeruginosa infection in mice and presents new molecules targeting the PqsE active site.

O-specific antigen-dependent surface hydrophobicity mediates aggregate assembly type in Pseudomonas aeruginosa

This study shows that O-specific antigen affects surface hydrophobicity, leading to different aggregate types in Pseudomonas aeruginosa under CF-like conditions.

Overproduction of the AlgT sigma factor is lethal to mucoid Pseudomonas aeruginosa

This study shows that overproduction of AlgT sigma factor is lethal in mucoid Pseudomonas aeruginosa and identifies mutations in mucP as suppressors that stabilize MucA22 to reduce toxicity.

Genotypic and phenotypic diversity of Staphylococcus aureus from cystic fibrosis lung infections and their interactions with Pseudomonas aeruginosa

This study analyzes the genotypic and phenotypic diversity of Staphylococcus aureus from cystic fibrosis lung infections and their interactions with Pseudomonas aeruginosa, finding that isolates retain virulence factors and exhibit varied survival responses to P. aeruginosa.

Substrate recognition by the Pseudomonas aeruginosa EF-Tu methyltransferase EftM

This study defines the molecular mechanism of EF-Tu substrate recognition by the Pseudomonas aeruginosa methyltransferase EftM through computational modeling and experimental validation.