Author

L. Rauova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Sarkar· 4 shared M. Poncz· 4 shared D. B. Cines· 2 shared M. A. Kowalska· 2 shared , H. J. Shukla· 1 shared , V. V. Inamdar· 1 shared A. C. Huang· 1 shared A. E. Aghali· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersCell Biology

A. Sarkar

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Neutrophil extracellular trap stabilization by platelet factor 4 reduces thrombogenicity and endothelial cell injury

A. T. Ngo, A. Sarkar, I. Yarovoi, N. Levine, V. Bochenek, G. Zhao, L. Rauova, M. A. Kowalska, K. Eckart, N. Mangalmurti, A. Rux, D. B. Cines, M. Poncz, K. Gollomp

This study shows that stabilizing neutrophil extracellular traps (NETs) with platelet factor 4 reduces thrombogenicity and endothelial cell injury in sepsis.

bioRxiv · Jan 9, 2023 · PreprintCell Biology

Prevention of thrombocytopenia and thrombosis in heparin-induced thrombocytopenia (HIT) using deglycosylated KKO: A novel therapeutic?

A. Sarkar, S. Khandelwal, H. Kim, Y. Gruel, J. Rollin, G. D. Wool, G. M. Arepally, D. B. Cines, L. Rauova, M. Poncz

This paper demonstrates that deglycosylated KKO (DGKKO) can prevent and reverse thrombocytopenia and thrombosis in a HIT murine model.

bioRxiv · Oct 19, 2022 · PreprintCell Biology

Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19

S. A. Apostolidis, A. Sarkar, H. M. Giannini, R. R. Goel, D. Mathew, A. Suzuki, A. E. Baxter, A. R. Greenplate, C. Alanio, M. Abdel-Hakeem, D. A. Oldridge, J. R. Giles, J. E. Wu, Z. Chen, Y. J. Huang, , E. J. Wherry

This study identifies FcγRIIA and C5a-C5aR pathways as mediators of platelet hyperactivation in COVID-19 patients, showing their role in thrombotic complications.

Frontiers in Immunology · Mar 3, 2022Peer-reviewedImmunology

Inhibition and down regulation of the serotonin transporter contribute to the progression of degenerative mitral regurgitation

R. J. Levy, E. Fitzpatrick, E. Castillero, , H. J. Shukla, , V. V. Inamdar, A. E. Aghali, J. B. Grau, N. Rioux, E. Salvati, S. J. Keeney, I. Nissim, R. C. C. Gorman, L. Rauova, S. J. Stachelek, C. R. Brown, , G. Ferrari

This study investigates how inhibition and downregulation of the serotonin transporter (SLC6A4) contribute to the progression of degenerative mitral regurgitation through enhanced HTR2B signaling.

bioRxiv · Mar 10, 2020 · PreprintPhysiology

Neutrophil extracellular trap stabilization leads to improved outcomes in murine models of sepsis

K. L. Gollomp, A. Sarkar, S. Seeholzer, L. Rauova, M. A. Kowalska, M. Poncz

This study shows that stabilizing neutrophil extracellular traps (NETs) with PF4 and KKO improves outcomes in sepsis by reducing NET degradation products and enhancing bacterial capture.

bioRxiv · May 7, 2019 · PreprintImmunology