M. Aikawa

PARP14 is an interferon (IFN)-induced host factor that promotes IFN production and affects the replication of multiple viruses

This paper shows PARP14 promotes IFN production and has both antiviral and proviral functions against multiple viruses.

Interplay Between FoxM1 and Dab2 Promotes Endothelial Cell Responses in Diabetic Wound Healing

This study identifies Dab2 and FoxM1 as key regulators of endothelial dysfunction in diabetes, showing that restoring Dab2 improves angiogenesis and wound healing.

Single-cell T cell receptor sequencing of paired tissue and blood samples reveals clonal expansion of CD8+ effector T cells in patients with calcific aortic valve disease

The paper uses single-cell T cell receptor sequencing to analyze paired tissue and blood samples from CAVD patients, identifying clonal expansion of CD8+ effector T cells and potential epitope targets in the valve.

Intracellular Proteomics and Extracellular Vesiculomics as a Metric of Disease Recapitulation in 3D Bioprinted Aortic Valve Arrays

This study compares 3D-bioprinted and 2D models of calcific aortic valve disease using proteomics and vesiculomics to assess disease recapitulation.

Second Heart Field-derived Cells Contribute to Angiotensin II-mediated Ascending Aortopathies

This study shows SHF-derived cells contribute to AngII-induced ascending aortic pathologies through LRP1 and TGF-β signaling, increasing PAI1 expression.