Author

D. C. Akuma

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Assay:proteomics· 1

Frequent Co-Authors

D. Grubaugh· 2 shared I. E. Brodsky· 2 shared S. Shin· 2 shared C. E. Odunze· 1 shared C. Y. Taabazuing· 1 shared E. M. Harberts· 1 shared R. K. Ernst· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 17 mutual co-author links

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2 shared papersImmunology

D. Grubaugh

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2 papers

Recent·Most cited

Noncanonical inflammasome assembly requires caspase-11 catalytic activity and intra-molecular autoprocessing

D. C. Akuma, D. Grubaugh, C. E. Odunze, S. Shin, C. Y. Taabazuing, I. E. Brodsky

This study shows that Casp11 catalytic activity and autoprocessing are required for noncanonical inflammasome assembly and LPS-induced speck formation in macrophages.

bioRxiv · Sep 21, 2022Immunology

Position-specific secondary acylation determines detection of lipid A by murine TLR4 and caspase-11

E. M. Harberts, D. Grubaugh, D. C. Akuma, S. Shin, R. K. Ernst, I. E. Brodsky

The paper investigates how position-specific secondary acyl chains on lipid A affect TLR4 and Casp11 activation, revealing distinct structural requirements for each receptor.

bioRxiv · Dec 16, 2021Immunology