Author

D. Grubaugh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

I. E. Brodsky· 4 shared S. Shin· 3 shared D. C. Akuma· 2 shared E. M. Harberts· 2 shared R. K. Ernst· 2 shared A. A. DeLaney· 1 shared A. R. Bass· 1 shared B. C. Schaefer· 1 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersImmunology

I. E. Brodsky

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Noncanonical inflammasome assembly requires caspase-11 catalytic activity and intra-molecular autoprocessing

D. C. Akuma, D. Grubaugh, C. E. Odunze, S. Shin, C. Y. Taabazuing, I. E. Brodsky

This study shows that Casp11 catalytic activity and autoprocessing are required for noncanonical inflammasome assembly and LPS-induced speck formation in macrophages.

bioRxiv · Sep 21, 2022Immunology

Position-specific secondary acylation determines detection of lipid A by murine TLR4 and caspase-11

E. M. Harberts, D. Grubaugh, D. C. Akuma, S. Shin, R. K. Ernst, I. E. Brodsky

The paper investigates how position-specific secondary acyl chains on lipid A affect TLR4 and Casp11 activation, revealing distinct structural requirements for each receptor.

bioRxiv · Dec 16, 2021Immunology

Human TLR4 and noncanonical inflammasome differ in their ability to respond to distinct lipid A variants

J. Alexander-Floyd, A. R. Bass, E. M. Harberts, D. Grubaugh, J. D. Buxbaum, I. E. Brodsky, R. K. Ernst, S. Shin

The paper compares how human TLR4 and noncanonical inflammasome sensors CASP4/5 respond to different lipid A structures, finding that acylation state differentially affects their activation.

bioRxiv · Dec 16, 2021 · PreprintImmunology

Genetic targeting of Card19 is linked to disrupted Ninj1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection

E. Bjanes, R. G. Sillas, R. Matsuda, B. Demarco, T. Fettrelet, A. A. DeLaney, O. S. Kornfeld, B. L. Lee, E. M. Rodriguez Lopez, D. Grubaugh, M. A. Wynosky-Dolfi, N. H. Philip, E. Krespan, D. Tovar, L. Joannas, , I. E. Brodsky

This study shows that genetic targeting of Card19 disrupts Ninj1 expression, impairs macrophage cell lysis, and increases susceptibility to Yersinia infection.

bioRxiv · Mar 19, 2021 · PreprintImmunology