ASSESSING TARGET SPECIFICITY OF THE SMALL MOLECULE INHIBITOR MARIMASTAT TO SNAKE VENOM TOXINS: A NOVEL APPLICATION OF THERMAL PROTEOME PROFILING
C. F. Smith, C. M. Modahl, D. Ceja-Galindo, K. Y. Larson, S. P. Maroney, L. Bahrabadi, N. P. Brandehoff, B. W. Perry, M. C. McCabe, D. Petras, B. Lomonte, J. J. Calvete, T. A. Castoe, S. P. Mackessy, K. C. Hansen, A. J. Saviola
This study uses Thermal Proteome Profiling and PISA to assess marimastat's specificity against snake venom toxins, identifying its targets and interactions with specific proteoforms.
bioRxiv · Oct 25, 2023Biochemistry