Author

C. M. Modahl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Evolutionary Biology· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Approach:statistical model· 2 Organism:Arabidopsis· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. J. Saviola· 2 shared R. M. Kini· 2 shared S. P. Mackessy· 2 shared A. Chowdhury· 1 shared B. Lomonte· 1 shared B. W. Perry· 1 shared B. Wong· 1 shared C. A. Dawson· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

A. J. Saviola

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

ASSESSING TARGET SPECIFICITY OF THE SMALL MOLECULE INHIBITOR MARIMASTAT TO SNAKE VENOM TOXINS: A NOVEL APPLICATION OF THERMAL PROTEOME PROFILING

C. F. Smith, C. M. Modahl, D. Ceja-Galindo, K. Y. Larson, S. P. Maroney, L. Bahrabadi, N. P. Brandehoff, B. W. Perry, M. C. McCabe, D. Petras, B. Lomonte, J. J. Calvete, T. A. Castoe, S. P. Mackessy, K. C. Hansen, A. J. Saviola

This study uses Thermal Proteome Profiling and PISA to assess marimastat's specificity against snake venom toxins, identifying its targets and interactions with specific proteoforms.

bioRxiv · Oct 25, 2023Biochemistry

Dermonecrosis caused by spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib

K. E. Bartlett, S. R. Hall, S. A. Rasmussen, E. Crittenden, C. A. Dawson, L.-O. Albulescu, W. M. Laprade, R. A. Harrison, A. J. Saviola, C. M. Modahl, T. P. Jenkins, M. C. Wilkinson, J. M. Gutierrez, N. R. Casewell

This study identifies toxin synergism in spitting cobra venom causing dermonecrosis and shows that varespladib prevents tissue damage in mouse models.

bioRxiv · Jul 20, 2023Pharmacology & Toxicology

Distinct regulatory networks control toxin gene expression in elapid and viperid snakes

C. M. Modahl, X. Han, J. van Thiel, C. Vaz, N. L. Dunstan, S. Frietze, T. N. W. Jackson, S. P. Mackessy, R. M. Kini

This study compares regulatory networks of toxin gene expression in elapid and viperid snakes, finding distinct histone methylation, transcription factor, and microRNA regulation between the families.

bioRxiv · Feb 13, 2023Evolutionary Biology

JNK pathway restricts DENV, ZIKV and CHIKV infection by activating complement and apoptosis in mosquito salivary glands

A. Chowdhury, C. M. Modahl, S. T. Tan, B. Wong, D. Misse, T. Vial, R. M. Kini, J. Pompon

The paper identifies the JNK pathway's role in restricting dengue, Zika, and chikungunya virus infection in mosquito salivary glands by activating complement and apoptosis.

bioRxiv · Mar 1, 2020Microbiology