Author

A. J. Saviola

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

K. C. Hansen· 3 shared C. M. Modahl· 2 shared M. C. McCabe· 2 shared A. Barrett· 1 shared A. Burlingame· 1 shared A. J. York· 1 shared B. Lomonte· 1 shared B. W. Perry· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiochemistry

K. C. Hansen

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Assessing Heterogeneity in the N-Telopeptides of Type I Collagen by Mass Spectrometry

Z. Darula, M. C. McCabe, A. Barrett, L. R. Schmitt, M. D. Maslanka, A. J. Saviola, J. Orgel, A. Burlingame, C. A. Staab-Weijnitz, K. Stenmark, V. Weaver, R. J. Chalkley, K. C. Hansen

The paper develops a method to identify N-terminal cross-linked peptides from collagen I in Achilles tendon using mass spectrometry, revealing differences in cross-links in bovine pulmonary hypertension.

bioRxiv · Mar 31, 2024 · PreprintBiochemistry

ASSESSING TARGET SPECIFICITY OF THE SMALL MOLECULE INHIBITOR MARIMASTAT TO SNAKE VENOM TOXINS: A NOVEL APPLICATION OF THERMAL PROTEOME PROFILING

C. F. Smith, C. M. Modahl, D. Ceja-Galindo, K. Y. Larson, S. P. Maroney, L. Bahrabadi, N. P. Brandehoff, B. W. Perry, M. C. McCabe, D. Petras, B. Lomonte, J. J. Calvete, T. A. Castoe, S. P. Mackessy, K. C. Hansen, A. J. Saviola

This study uses Thermal Proteome Profiling and PISA to assess marimastat's specificity against snake venom toxins, identifying its targets and interactions with specific proteoforms.

bioRxiv · Oct 25, 2023Biochemistry

Dermonecrosis caused by spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib

K. E. Bartlett, S. R. Hall, S. A. Rasmussen, E. Crittenden, C. A. Dawson, L.-O. Albulescu, W. M. Laprade, R. A. Harrison, A. J. Saviola, C. M. Modahl, T. P. Jenkins, M. C. Wilkinson, J. M. Gutierrez, N. R. Casewell

This study identifies toxin synergism in spitting cobra venom causing dermonecrosis and shows that varespladib prevents tissue damage in mouse models.

bioRxiv · Jul 20, 2023Pharmacology & Toxicology

Cardiac fibroblasts regulate cardiomyocyte hypertrophy through dynamic regulation of type I collagen

Q. Meng, S. L. K. Bowers, Y. Kuwabara, J. Huo, R. Minerath, A. J. York, M. A. Sargent, V. Prasad, A. J. Saviola, D. C. Galindo, K. C. Hansen, R. J. Vagnozzi, K. E. Yutzey, J. D. Molkentin

This study shows that type I collagen produced by cardiac fibroblasts regulates cardiomyocyte hypertrophy and fibrosis, with developmental and acute deletion effects on cardiac function.

bioRxiv · May 25, 2022 · PreprintCell Biology