Author

J. J. Calvete

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

D. Petras· 2 shared H. W. Greene· 2 shared L.-O. Albulescu· 2 shared N. R. Casewell· 2 shared R. A. Harrison· 2 shared S. Ainsworth· 2 shared A. Barlow· 1 shared A. Heap· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

D. Petras

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Author profile →

4 papers

Recent·Most cited

ASSESSING TARGET SPECIFICITY OF THE SMALL MOLECULE INHIBITOR MARIMASTAT TO SNAKE VENOM TOXINS: A NOVEL APPLICATION OF THERMAL PROTEOME PROFILING

C. F. Smith, C. M. Modahl, D. Ceja-Galindo, K. Y. Larson, S. P. Maroney, L. Bahrabadi, N. P. Brandehoff, B. W. Perry, M. C. McCabe, D. Petras, B. Lomonte, J. J. Calvete, T. A. Castoe, S. P. Mackessy, K. C. Hansen, A. J. Saviola

This study uses Thermal Proteome Profiling and PISA to assess marimastat's specificity against snake venom toxins, identifying its targets and interactions with specific proteoforms.

bioRxiv · Oct 25, 2023Biochemistry

Convergent Evolution of Pain-Inducing Defensive Venom Components in Spitting Cobras

T. D. Kazandjian, D. Petras, S. D. Robinson, J. van Thiel, H. W. Greene, K. Arbuckle, A. Barlow, D. A. Carter, R. M. Wouters, G. Whiteley, S. C. Wagstaff, A. S. Arias, L.-O. Albulescu, A. von Plettenberg Laing, C. Hall, , N. R. Casewell

This study shows that three spitting cobra lineages independently evolved venom with increased pain-enhancing toxins, likely in response to hominin emergence.

bioRxiv · Jul 8, 2020Evolutionary Biology

Preclinical validation of a repurposed metal chelator as a community-based therapeutic for hemotoxic snakebite

L.-O. Albulescu, M. Hale, S. Ainsworth, J. Alsolaiss, E. Crittenden, J. J. Calvete, M. C. Wilkinson, R. A. Harrison, J. Kool, N. R. Casewell

This paper shows that the metal chelator DMPS can effectively treat hemotoxic snakebite in mice, both when given orally and in combination with antivenom.

bioRxiv · Jul 28, 2019Pharmacology & Toxicology

When one phenotype is not enough - divergent evolutionary trajectories govern venom variation in a widespread rattlesnake species

G. Zancolli, J. J. Calvete, M. D. Cardwell, H. W. Greene, W. K. Hayes, M. J. Hegarty, H.-W. Herrmann, A. T. Holycross, D. I. Lannutti, J. F. Mulley, L. Sanz, Z. D. Travis, J. R. Whorley, C. E. Wuster, W. Wuster

This study shows that venom variation in rattlesnakes is driven by divergent selective pressures acting on separate toxin genes, not diet or neutral population structure.

bioRxiv · Sep 12, 2018Evolutionary Biology